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Qualitative and quantitative methods will be adopted for the case studies, including mapping, spatial analysis, surveys, and interviews

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NNMT enzyme inhibition occurs within 24 hours of subcutaneous dosing based on pharmacokinetic modelling, but downstream metabolic effects NAD+ elevation, changes in fat oxidation markers typically require 24 weeks of consistent dosing to manifest in measurable endpoints

J.TonasciaJ.et al (2017)

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Prioritize metformin where indicated, inositol, and peptides that improve insulin sensitivity